Synthesis and Biological Evaluation of N-heterocycles for Activity on Monoamine Transporters and Exploration of Iridium Chemistry for Synthesis of Medicinally Important Molecules

.................................................................................................................ix Chapter 1: Design, synthesis and evaluation of novel piperidine derivatives for monoamine transporter affinity .......................................................................................................................... 1 1.1. Abstract .................................................................................................................................... 1 1.2. Introduction .............................................................................................................................. 1 1.3. Design of new Pharmacophore .............................................................................................. 16 1.4. Objectives............................................................................................................................... 17 1.5. Results and Discussion .......................................................................................................... 19 1.6. Conclusion ............................................................................................................................. 22 1.7. Experimental .......................................................................................................................... 23 1.8. References .............................................................................................................................. 69 Chapter 2: Design, synthesis and pharmacological evaluation of 3-aryl-3-aryl pyrrolidines as monoamine transporter ligands ..................................................................................................... 74 2.1. Abstract .................................................................................................................................. 74 2.2. Introduction ............................................................................................................................ 74 2.3. Results and discussion ........................................................................................................... 75 2.5. Conclusion ............................................................................................................................. 78 2.6. Experimental .......................................................................................................................... 78 2.7. References ............................................................................................................................ 105 Chapter 3. Application of Iridium catalyzed N-heterocyclization for synthesis of Natural products. ..................................................................................................................................... 106